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Whether you’ve just begun your wellness journey or are a long-term health enthusiast, there’s one natural compound that’s worth turning your attention to – Berberine. A powerhouse of benefits, Berberine is an alkaloid extracted from various plants, including the group of shrubs known as Berberis. It has been part of traditional Chinese and Ayurvedic medicine for centuries, but only recently has its value been recognized in the realm of modern science.

So why should you consider incorporating Berberine into your wellness routine? Here’s why.

1: Regulation of Metabolism [1]

An illustration of representative of a human female's metabolism

At the heart of Berberine’s health benefits lies its remarkable ability to regulate metabolism. This yellow-colored compound has been found to activate an enzyme known as Adenosine Monophosphate-Activated Protein Kinase (AMPK).

Considered as the “metabolic master switch,” AMPK regulates how the body uses energy and has an influence on a wide variety of bodily functions, including fat and sugar metabolism. By activating this enzyme, Berberine essentially supports the efficient use of energy in your body, preventing it from storing excess fat.

2: Blood Sugar Control [2]

Berberine capsules next to a blood glucose meter

Perhaps one of the most impressive benefits of Berberine is its remarkable ability to lower blood sugar levels. Its effects have been found to have similar methods of action to commonly prescribed diabetes drugs. This property has sparked considerable interest in Berberine, especially for individuals looking for natural ways to manage their blood sugar levels.

Berberine’s impact on blood sugar control works in several ways. First, it helps decrease insulin resistance, which makes the insulin in your body more effective at ushering sugar into your cells. This process aids in lowering blood sugar levels and keeping them stable.

Berberine also has the ability to increase insulin production, making more of this crucial hormone available to move sugar out of your bloodstream and into your cells where it can be used as energy.

Another beneficial mechanism is that Berberine slows the breakdown of carbohydrates in the gut. By doing so, it reduces the amount of glucose that enters your bloodstream, preventing sudden spikes in blood sugar levels that can occur after meals.

Finally, Berberine also helps reduce sugar production in the liver, further supporting the maintenance of stable blood sugar levels.

Together, these mechanisms highlight Berberine’s remarkable potential as a natural aid in controlling blood sugar. By helping to stabilize blood sugar levels, Berberine also supports energy balance and weight management, making it an all-around beneficial addition to a healthy lifestyle.

3: Weight Management [3]

Bright yellow berberine capsules ona bathroom scale.

The journey towards a healthy weight can be a challenging one, especially as we age and our metabolism begins to slow down. Berberine can be a powerful ally in this journey, offering substantial benefits for weight management. Its unique ability to improve metabolic functions and stabilize blood sugar levels makes it a compelling choice for those seeking natural weight management solutions.

Berberine helps to activate an enzyme called Adenosine Monophosphate-Activated Protein Kinase (AMPK), often referred to as the “metabolic master switch.” Activation of AMPK helps to boost metabolism, increasing the rate at which your body converts nutrients into energy. This action can lead to a reduction in fat storage, helping you to maintain a healthy weight more easily.

By managing blood sugar levels, Berberine further supports weight control. Stable blood sugar prevents sudden drops that can trigger feelings of hunger and cravings for sugary foods. By keeping your blood sugar steady, Berberine helps to control your appetite, reducing the likelihood of overeating and unwanted weight gain.

In addition, studies have shown that Berberine can help reduce belly fat and improve other health markers. Belly fat, in particular, can be hard to lose and is associated with an increased risk of several diseases. By helping to tackle this problem area, Berberine not only supports weight management but also contributes to overall health improvement.

4: Cardiovascular Health [4]

Berberine supports a healthy heart.

Cardiovascular disease remains a leading health concern, especially as we age. The good news is, Berberine has been shown to have multiple benefits for heart health.

Berberine can help lower LDL cholesterol, often referred to as “bad” cholesterol, and triglycerides, types of fats found in your blood. High levels of these fats can lead to the buildup of plaques in your arteries, increasing your risk of heart disease. By helping to reduce these levels, Berberine supports the health of your arteries and overall cardiovascular system.

Berberine also plays a role in managing blood pressure. High blood pressure can lead to a host of heart-related problems, including heart failure and stroke. Studies have shown that Berberine may help lower blood pressure, contributing to a healthy cardiovascular system.

Berberine is also known for its anti-inflammatory and antioxidant properties. Chronic inflammation and oxidative stress are key players in the development of heart disease. By minimizing inflammation and neutralizing harmful free radicals in your body, Berberine provides another level of protection for your heart.

5: Healthy Aging [5]

A middle aged woman that is aging gracefully.

Aging is a natural process that we all go through, but that doesn’t mean we can’t age gracefully and healthily. Berberine offers a number of properties that can aid in this process, primarily through its potent antioxidant and anti-inflammatory properties, making it a potentially beneficial supplement in an anti-aging regimen.

Berberine is a powerful antioxidant, meaning it combats free radicals in the body. Free radicals are unstable molecules that can cause damage to our cells, contributing to aging and various diseases. By neutralizing these harmful free radicals, Berberine can help protect our cells, potentially slowing down the aging process and promoting overall health.

As we mentioned earlier, Berberine also helps to activate an enzyme in our body known as AMPK. This enzyme, often referred to as a ‘metabolic master switch‘, is known to play a crucial role in regulating metabolism and maintaining cellular energy balance. This activation not only supports healthier metabolic function, but it also encourages the renewal of cells, which is crucial for maintaining a youthful appearance and overall well-being.

Furthermore, chronic inflammation is known to be a major contributor to the aging process and is linked to many age-related health problems. Berberine’s anti-inflammatory properties can help to manage and reduce chronic inflammation, supporting healthier aging and helping to prevent various health complications.

6: Supports Gut Health [6]

A healthy human gut

Gut health is integral to overall health. Our gut hosts trillions of bacteria, forming the gut microbiome, which plays a critical role in digestion, nutrient absorption, immune function, and even mood regulation. Berberine has been found to have a significant positive impact on gut health, contributing to a balanced gut microbiome.

Berberine possesses potent antimicrobial properties, enabling it to combat harmful bacteria in the gut without significantly affecting the beneficial bacteria. This ability is crucial in preventing and managing dysbiosis – an imbalance of gut bacteria that can lead to various health issues such as digestive problems, obesity, diabetes, and even mental health conditions.

In addition, Berberine has been found to promote the growth of certain beneficial bacteria species in the gut, such as Akkermansia muciniphila and Bifidobacterium. These bacteria play an essential role in maintaining gut health, supporting the immune system, and promoting metabolic health.

Furthermore, Berberine’s anti-inflammatory properties extend to the gut as well. It can help soothe inflammation within the gut lining, which is crucial in preventing leaky gut syndrome – a condition where toxins and bacteria leak into the bloodstream through gaps in the intestinal wall, leading to inflammation and other health issues.

The connection between gut health and overall health is significant and multifaceted. By promoting a balanced gut microbiome and reducing gut inflammation, Berberine contributes to improved digestion, enhanced immune function, and overall better health.

7: Enhanced Cognitive Function [7]

Berberine is brain healthy and can support improved cognitive function.

Berberine doesn’t just benefit your physical health; it can also be a potent ally for your brain. Various studies suggest that Berberine can significantly improve cognitive function and overall brain health, offering a comprehensive approach to mental wellness.

Berberine exerts its positive impact on cognition primarily through its powerful anti-inflammatory and antioxidant effects. Inflammation and oxidative stress can cause damage to brain cells over time and have been linked to cognitive decline and various neurodegenerative disorders. By mitigating these harmful processes, Berberine can help safeguard the brain and maintain optimal cognitive health.

Furthermore, it has been found to stimulate the process of neurogenesis, the growth, and development of new brain cells. This is particularly crucial as the creation of new neurons can enhance cognitive function and improve memory and learning capacities. Berberine’s ability to promote neurogenesis contributes to maintaining an active and healthy brain, even as we age.

There’s also compelling research suggesting that Berberine can have a positive impact on mood disorders such as depression and anxiety. It’s believed that Berberine can influence the regulation of neurotransmitters, including serotonin and dopamine, which play significant roles in mood regulation and overall mental health.

8: Improved Mood and Energy Levels [8]

A healthy and happy older woman working out.

Life is much more enjoyable when we feel happy and full of energy. Interestingly, Berberine may play a role in helping to enhance our mood and energy levels, offering significant potential benefits that can contribute to our overall quality of life.

When it comes to mood regulation, Berberine has been found to influence neurotransmitter processes in the brain. Neurotransmitters, including serotonin and dopamine, play a significant role in regulating our mood. Berberine is believed to enhance the activities of these neurotransmitters, potentially helping to alleviate mood disorders like depression and anxiety, thereby promoting a more positive mental state.

Berberine’s benefits extend to energy levels as well. Its role in activating the enzyme AMPK, the “metabolic master switch,” is key. This enzyme plays a critical role in regulating cellular energy. By activating AMPK, Berberine can help to optimize our energy metabolism, leading to increased energy levels.

Also, through its positive impact on blood sugar regulation and weight management, Berberine can contribute to enhanced energy levels. When our blood sugar levels are stable, and our weight is managed, we’re less likely to experience energy crashes, leading to more sustained energy throughout the day.

9: Reduces Inflammation [9]

Chronic inflammation in joints

Chronic inflammation can be a significant threat to our overall health. Linked to numerous diseases, from heart disease to diabetes, arthritis, and even depression, managing inflammation is a critical aspect of maintaining good health. Here’s where Berberine can play a crucial role.

Berberine has been found to have potent anti-inflammatory properties. It works by inhibiting the production of specific molecules that trigger inflammation in our body, thereby helping to keep inflammation under control. This is particularly beneficial because it means Berberine can help to mitigate the harmful effects of chronic inflammation, offering protection against various health conditions associated with it.

In addition, by reducing inflammation, Berberine can help alleviate symptoms of inflammatory diseases. For instance, in the case of arthritis, Berberine can potentially help to reduce joint pain and stiffness. In metabolic disorders like type 2 diabetes, its anti-inflammatory action can help to improve insulin sensitivity and blood sugar control.

10: Stronger Immune System [10]

A healthy older couple taking a berberine supplement

Having a strong immune system is crucial for staying healthy, particularly as we age. The immune system is our body’s primary line of defense against harmful pathogens like bacteria, viruses, and fungi. Berberine is a potent supplement that can provide valuable support to our immune system, helping us maintain our health and resist illnesses more effectively.

Berberine can aid our immune system in several ways. Its powerful antimicrobial properties enable it to fight off harmful bacteria, viruses, and fungi directly. This is particularly significant, as it means Berberine can help reduce the risk of various infections and diseases.

Berberine can also modulate the body’s immune response, helping to prevent overreactions of the immune system that can lead to autoimmune and inflammatory conditions. By helping to regulate immune response, Berberine can support a balanced and robust immune system.

11: Reduced Symptoms of Polycystic Ovary Syndrome (PCOS) [11]

Symptoms of Polycystic Ovary Syndrome, or PCOS.

Polycystic Ovary Syndrome, or PCOS, is a common endocrine disorder that affects many women in their reproductive years. It’s characterized by hormonal imbalances, irregular menstrual cycles, and the development of small cysts on the ovaries. Symptoms can include weight gain, acne, hair loss or excessive hair growth, and fertility issues. Studies suggest that Berberine could offer potential benefits in managing this condition.

One of the main ways Berberine can support women with PCOS is by helping to regulate insulin and glucose metabolism. Insulin resistance is often present in women with PCOS, leading to elevated insulin and blood sugar levels. Berberine’s ability to improve insulin sensitivity can help to correct these imbalances, reducing one of the major drivers of PCOS.

Moreover, Berberine has been shown to decrease androgen levels, the male hormones that are typically elevated in women with PCOS. High levels of these hormones can lead to some of the more distressing symptoms of PCOS, like hair loss and excessive hair growth. By helping to regulate these hormone levels, Berberine can potentially alleviate some of these symptoms.

In addition to its hormone-regulating effects, Berberine’s impact on weight management can also be beneficial for women with PCOS, who often struggle with weight gain due to their hormonal imbalances. As discussed earlier, Berberine’s ability to improve metabolic function and support weight loss can be of particular value to women dealing with this condition.

It’s crucial to note that while Berberine can be a supportive supplement for managing PCOS symptoms, it should not replace medical treatment for the condition. Always consult with a healthcare provider before starting any new supplement regimen, particularly if you have a diagnosed medical condition.

Which berberine brand is best?

We’re often asked which supplement brands we prefer. It’s a great question because not all berberine supplements are created equally. Quality, purity, dosage, and manufacturing practices can all vary significantly from brand to brand, making some supplements more effective and safer than others.

When choosing a Berberine supplement, there are several key factors to consider.

It’s crucial to check the amount of active Berberine in each serving. Some supplements may have a high dosage of Berberine, but only a small percentage is the active form that your body can use effectively. It’s generally recommended to look for supplements that contain more than 600 mg of active Berberine per serving.

Next, consider the supplement’s purity. A high-quality Berberine supplement should be free from common allergens, artificial additives, and unnecessary fillers. Some companies offer third-party testing results for their products, which can provide reassurance about the product’s purity and quality.

Look for a supplement that also contains Oregon Grape and Goldenseal. These are natural compounds that can enhance the effectiveness of the berberine.

The form of Berberine also matters. Berberine Hydrochloride (Berberine HCl) is a common and effective form that is readily absorbed by the body, but we always recommend the most natural form you can find. Look for Barberry (Berberis Vulgaris) Root Extract.

Manufacturing practices are another important consideration. Look for brands that adhere to Good Manufacturing Practices (GMP). This ensures that the product is made in a quality-controlled environment and meets certain standards for consistency and quality.

It’s always a good idea to check for company transparency. Brands that are open about their sourcing, manufacturing processes, and testing procedures generally produce higher quality, more trustworthy products.

Our Berberine Supplement Pick

Here at our TrustInform, we have done extensive research and reviewed many Berberine supplements, and we’ve found NativePath’s Native Berberine to be our top choice.

NativePath’s Native Berberine stands out for several reasons. Each capsule of NativePath’s Berberine contains a whopping 900mg of berberine (Barberry Root Extract). It also contains the beneficial extracts Oregon Grape and Goldenseal which help to increase the effectiveness of the berberine. This means you’re getting an effective dose in each serving, which is essential for achieving the potential health benefits of Berberine.

Secondly, NativePath prioritizes product purity and quality. Their Berberine supplement is free from common allergens, artificial additives, and unnecessary fillers. They utilize third-party testing to ensure product safety and potency, providing extra reassurance for users.

NativePath also offers the best stock-up-and-save discounts you can find. If they’re running one of these multi-bottle discounts, we highly recommend taking advantage. It’s a great way to save money while making sure you always have enough berberine on hand–it doesn’t work if you run out!

Native Berberine‘s adherence to recommended dosage, product purity, quality manufacturing practices, company transparency, and great deals make it a preferred choice for a Berberine supplement.

In Conclusion

In conclusion, Berberine, with its wide array of potential health benefits, can be a valuable addition to a health-conscious lifestyle. From aiding in weight loss and blood sugar control, supporting gut health and cognitive function, to reducing inflammation and boosting the immune system, Berberine offers a comprehensive approach to maintaining and enhancing health as we age.

With the right guidance, and a quality supplement, incorporating Berberine into your routine can help support your health journey, allowing you to lead a vibrant and fulfilling life even in your later years. It’s always a good idea to check with your healthcare provider before starting any supplement. Here’s to a future filled with health, vitality, and well-being!



  1. https://journals.physiology.org/doi/full/10.1152/ajpendo.00211.2007?view=long&pmid=17971514&
  2. https://europepmc.org/article/med/28822177
  3. https://www.sciencedirect.com/science/article/pii/S0753332220303292
  4. https://www.tandfonline.com/doi/abs/10.1517/14712598.2013.776037
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758350/
  6. https://www.sciencedirect.com/science/article/abs/pii/S1043661820301493
  7. https://www.frontiersin.org/articles/10.3389/fphar.2022.917375/full
  8. https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.13930
  9. https://www.sciencedirect.com/science/article/abs/pii/S0304383503005949
  10. https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.7407
  11. https://link.springer.com/article/10.1007/s00404-020-05450-4